Nanoparticle Synthesis

Flame Spray Pyrolysis

We use flame spray pyrolysis for the scalable and reproducible manufacture of functional nanoparticles. We have advanced the flame synthesis of nanoparticles by developing a reactor that produces in a single step core-shell nanoparticles with fine and independent control over core particle properties and shell coating thickness. A wide spectrum of materials can be produced with this technology, such as magnetic (superparamagnetic iron oxide: SPION), plasmonic (Au, Ag) or luminescent (nanophosphors) nanoparticles. We employ rigorous solid state characterization of our nanomaterials to ensure reproducibility. Silica (SiO2) is chosen as shell material as it is the most preferred coating material for biomedical applications due to its chemical stability and biocompatibility. It also enables the facile surface functionalization of such nanoparticles with targeting ligands to selected disease biomarkers.

Synthesis of SiO2 coated SPION

Teleki, A., M.C. Heine, F. Krumeich, M.K. Akhtar, and S.E. Pratsinis, “In situ coating of flame-made TiO2 particles with nanothin SiO2 films” Langmuir . 24, 12553-12558 (2008).

Teleki, A., M.K. Akhtar, and S.E. Pratsinis, “The quality of SiO2 coatings on flame-made TiO2-based nanoparticles,” J. Mater. Chem. 18, 3547-3555 (2008).

Teleki, A., B. Buesser, M.C. Heine, F. Krumeich, M.K. Akhtar, and S.E. Pratsinis, “Role of gas-aerosol mixing during in situ coating of flame-made titania particles” Ind. Eng. Chem. Res. 48, 85-92 (2009).